The Aging Gene Database gives information about genes and interventions that are linked to aging.
If you type in your favorite gene query, and the genes happens to be aging-related, then you are likely to see the Aging Gene Database respond with some descriptive information about your gene.
In the following example we search for the polgA gene by typing in gene:polg
Under the Nervous System Level filter, Genes, we can find the Aging Genes database, which has an entry for PolgA. We find out that PolgA is a mouse gene that decreases life-span because of an increase in point mutations of mitochondrial DNA.
If you click on the Blue link on the gene name you will be brought to the Aging Genes Database, where you will have to click again on PolgA to get more information.
The following page is the summary data for PolgA, with links to Pubmed as well as NCBI gene.
Interventions such as calorie restriction, various pharmaceutical agents, or supplements have effects on aging in various organisms and these are listed in the Aging Gene Database, under interventions.
Below, we search for glucose.
Under the Nervous System Level filter, Nervous System Function, the Aging Interventions are listed (see name in red). In the case of the current search D-Glucose was used to extend the life of yeast as a function of SIR2 interaction.
Clicking on the intervention name leads to the Aging Genes Database where you will have to click one more time to get to the specific study information.
NIF Version: 5.0
Ontology Version: 2.5
Level 2.5/3.0 Resources: 889
Registry Entries: 6,339
Total Records: 356,197,652